Mutual Purpose. Shared Innovation.

by Mark Gonzalez, PharmD, PCCA Clinical Compounding Pharmacist

Your “purpose” to help patients and providers is what motivates us to innovate, create, test, formulate and introduce new bases.

Behind every new base and subsequent formulation development, our purpose is to help you create in the lab, help patients and providers in new and exciting ways, and ultimately strengthen the relationships you have worked so hard to build and maintain.

Our revolutionary new base, EctoSeal P2G, is no exception in our purpose to serve you, your patients and prescribers.

CREATE

EctoSeal P2G is one of the first bases in the industry to combine a variety of clinical applications with three different dosage forms: topical powder, topical powder for reconstitution and topical hydrogel. The flexibility that comes with this base is unparalleled.

EctoSeal P2G can be mixed with a variety of active pharmaceutical ingredients (APIs) that, after dispensing and at time of use, can be insufflated — or sprinkled —directly onto a wound. Dispensing in a topical powder dosage form provides the potential for longer beyond-use dates for your pharmacy and convenience for your patients. The topical powder dosage form absorbs the exudate of wet wounds and quickly transforms into a hydrogel that, as it dries, forms a protective film that may help APIs better adhere to the wound bed. In addition, the protective film can potentially secure a moistened environment.

For dry wounds, the powder can be applied directly to the wound and moistened with purified water, sterile water or saline to induce the film-forming effect. The topical powder application is helpful with larger, deeper wounds, and also has excellent application for common abrasions, burns and exudative, eruptive sites of infection.

EctoSeal P2G can also be dispensed as a topical powder for reconstitution, where the powder is mixed with appropriate API(s), brought to volume (q.s.) with maltodextrin and dispensed in a jar. At time of use, the compounded preparation is measured in level scoops and placed in a medicine cup. Purified water, sterile water or saline is then added, and the preparation is mixed by hand for about 15 seconds to create a hydrogel, which is then applied to the affected area. When dispensed as a powder for reconstitution, most EctoSeal P2G compounds can be assigned a BUD of 180 days.

Dispensing as a topical hydrogel dosage form is another option. To dispense as a topical hydrogel, the EctoSeal P2G powder is first mixed with relevant APIs, then with an appropriate wetting agent, preservative and purified water. When dispensed as a hydrogel, the BUD should not exceed more than 14 days if unpreserved.

Regardless of dosage form, when moistened, EctoSeal P2G forms a strong yet pliable film as it dries. The protective film may provide longer-term delivery of APIs. In addition, the preparation develops a mostly clear thin film as it dries, allowing a protective, moist environment recognized to help wound healing. Even better, EctoSeal P2G easily reverts from a film to a gel when remoistened, making wound cleaning easier and less painful for patients.

HELP

As soon as I was introduced to this base during pre-launch discussions, my mind began to race with all of the potential applications and how they would be able to help patients, as well as help practitioners prescribe a potentially more efficacious, patient-friendly and environmentally-friendly option. Specialties such as:

• Wound care
• Post-surgical care (e.g., initial care of suture sites)
• Hospice
• Geriatrics
• Dermatology (e.g., acne, warts, infections, hidradenitis supurativa)
• Pediatrics
• Podiatry (e.g., onychomycosis, ingrown toenail pain relief)
• Proctology (e.g., external hemorrhoids/fissures)
• Veterinary

Strengthen

You became a compounder with the objective of being able to create preparations, help patients and strengthen your relationships with patients and providers. EctoSeal P2G is an exciting way to reignite those initial passions or flame your passions as a novice compounder.

Don’t let EctoSeal P2G be another base that you wait years to use. Take advantage of its versatility, ease of application and the potential promise to help you solve some of the most common medical issues confronting patients, providers and your pharmacy. Experience EctoSeal P2G today to create topical preparations, help your patients and build relationships with prescribers within your community. Members with clinical service access may contact the Clinical Services team for additional help with EctoSeal P2G or other compounding concerns.

Tune in to the Mortar & Pestle podcast to hear PCCA Chief Scientific Officer Gus Bassani and PCCA Director of Research and Development Daniel Banov discuss the science behind our revolutionary new base.

A complete version of this article originally appeared in PCCA’s members-only magazine, the Apothagram.

These statements are provided for educational purposes only. They have not been evaluated by the Food and Drug Administration, and are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care or encourage its abandonment.