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In the race to unlock the secrets of longevity, one of the most exciting areas of research is mitochondrial health. These tiny organelles, often referred to as the "powerhouses" of the cell, are responsible for producing the energy (ATP) that fuels every cell in the body. As we age, mitochondrial function tends to decline, leading to reduced energy, increased oxidative stress and accelerated aging. Maximizing mitochondrial health has emerged as a key strategy for extending both lifespan and health span — how long we live and how well we live.1
Recent research has identified several pathways to optimize mitochondrial function. One major discovery involves the molecule nicotinamide adenine dinucleotide (NAD+), which plays a crucial role in mitochondrial energy production.2 As we age, NAD+ levels decline, leading to less efficient energy production and greater cellular damage. Boosting NAD+ through precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) has shown promise in improving mitochondrial function and extending the lifespan of various organisms in laboratory studies.3 How this translates to human longevity — that is the question!
Another fascinating area is mitophagy, the process by which cells clear out damaged or dysfunctional mitochondria. With age, the body's ability to efficiently remove these damaged mitochondria diminishes, leading to cellular dysfunction. Promoting mitophagy through intermittent fasting or caloric restriction can help maintain a population of healthy mitochondria, thereby improving metabolic efficiency and reducing oxidative stress. Compounds such as creatine and urolithin A have been shown to stimulate mitophagy, offering potential therapeutic benefits for aging populations.4,5
Maintaining optimal hormone levels as we age plays a crucial role in supporting mitochondrial health. Hormones like estrogen, testosterone and thyroid hormones are vital regulators of mitochondrial function, helping to enhance mitochondrial biogenesis (the creation of new mitochondria) and optimize energy production. Adequate levels of these hormones, monitored through optimal testing, also promote mitochondrial repair.10
By integrating these strategies on a regular basis, we can enhance mitochondrial function, slow down the aging process and increase both lifespan and health span for a brighter, more energized future.
These statements are provided for educational purposes only. They have not been evaluated by the Food and Drug Administration, and are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care or encourage its abandonment.