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Abstract: Evaluation of the In Vitro Human Trunk Skin Percutaneous Absorption of Active Substances Incorporated Simultaneously in Lipoderm and Lipoderm ActiveMax


The in vitro human trunk skin percutaneous absorption of transdermal compounded formulations containing four active substances – Ketamine HCl, Gabapentin, Clonidine HCl and Baclofen – incorporated simultaneously in Lipoderm and also in Lipoderm ActiveMax, was evaluated using the Franz Skin Finite Dose Model. The Franz Skin Finite Dose Model was selected to evaluate the total absorption, rate of absorption and the skin content of the four active substances simultaneously applied to the outer surface of the skin.

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